The Guane were a South American people that lived mainly in the area of Santander and north of Boyacá, both departments of present-day central-Colombia. They were farmers cultivating cotton, pineapple and other crops, and skilled artisans working in cotton textiles. The Guane lived north of the Chicamocha River, around the Chicamocha Canyon in an area stretching from Vélez in the south to the capital of Santander; Bucaramanga in the north. Other sources state their territory did not extend so far north. Guane, a corregimiento of Barichara, Santander, is said to have been the capital of the Guane people.

The U'wa are an indigenous people living in the cloud forests of northeastern Colombia. Historically, the U'wa numbered as many as 20,000, scattered over a homeland that extended across the Venezuela-Colombia border. Some 7-8,000 U'wa are alive today.