Guangzhou–Zhuhai intercity railway or Guangzhu intercity railway is a dedicated, grade-separated regional railway linking Guangzhou South railway station in Panyu, Guangzhou, Jiangmen railway station in Xinhui, Jiangmen,and Zhuhai Jinwan Airport in Zhuhai, via Shunde, Zhongshan and Jiangmen, in Guangdong province. It is the first line completed in the Pearl River Delta Metropolitan Region intercity railway network. It is operated by China Railway Guangzhou Group.

Guangzhounan railway station is located in Shibi, Panyu District, Guangzhou, Guangdong Province, China. It is a large modern rail terminal 17 kilometres (11 mi) south of central Guangzhou. For a brief time it was Asia's largest railway station by area when it officially started operation in early 2010.