Guardian Angel Cathedral is a Catholic cathedral in Winchester, Nevada, United States, in the Las Vegas Valley. It is just off the Las Vegas Strip, north of the Encore hotel. It is the seat of the Archdiocese of Las Vegas. Before the establishment of the Diocese of Las Vegas in 1995, it was a parish of the Diocese of Reno.

The Archdiocese of Las Vegas is a Latin Church ecclesiastical territory, or archdiocese, of the Catholic Church in southern Nevada, United States.