Guelmim-Oued Noun is one of the twelve regions of Morocco. The southeastern part of the region is located in the disputed territory of Western Sahara and a small strip of land in this area is administered by the Sahrawi Arab Democratic Republic. The region as a whole covers an area of 46,108 km2 and had a population of 433,757 as of the 2014 Moroccan census. The capital of the region is Guelmim.

Regions are currently the highest administrative divisions in Morocco. Since 2015, Morocco officially administers 12 regions, including one that lies completely within the disputed territory of Western Sahara and two that lie partially within it. The regions are subdivided into a total of 75 second-level administrative divisions, which are prefectures and provinces.