Guilderland is a town in Albany County, New York, United States. In the 2020 census, the town had a population of 36,848. The town is named for the Gelderland province in the Netherlands. The town of Guilderland is on the central-northwest border of the county. It is just west of Albany, the capital of the U.S. state of New York.

Guilderland High School is a public senior high school, located in Guilderland Center, New York. It is part of the Guilderland Central School District. Constructed in 1953, the high school has since undergone additions in 1955, 1960, 1997, 2010, and 2021. Originally, the building functioned as a Junior-Senior High School, but after the construction of Farnsworth Middle School in 1970, the district divided the schools into two. As a school, Guilderland High School's enrollment jurisdiction also includes the village of Altamont, NY and the North Bethlehem neighborhood of Bethlehem, NY.