Guilderland Center is a hamlet in the town of Guilderland, Albany County, New York, United States. The hamlet lies along New York Route 146 and the Black Creek, a tributary of the Normans Kill.

Guilderland High School is a public senior high school, located in Guilderland Center, New York. It is part of the Guilderland Central School District. Constructed in 1953, the high school has since u