Guilford is a town in Chenango County, New York, United States. The town is on the eastern border of the county. The population was 2,922 at the 2010 census.

Chenango County is a county located in the south-central section U.S. state of New York. As of the 2020 census, the population was 47,220. Its county seat is Norwich. The county's name originates from an Oneida word meaning 'large bull-thistle'. The county is part of the Southern Tier region of the state.