The Guinea Pig Club, established in 1941, was a social club and mutual support network for British and allied aircrew injured during World War II. Its membership was made up of patients of Archibald McIndoe in Ward III at Queen Victoria Hospital, East Grinstead, Sussex, who had undergone experimental reconstructive plastic surgery, including facial reconstruction, generally after receiving burns injuries in aircraft. The club remained active after the end of the war, and its annual reunion meetings continued until 2007.

Sir Archibald Hector McIndoe was a New Zealand plastic surgeon who worked for the Royal Air Force during the Second World War. He improved the treatment and rehabilitation of badly burned aircrew.