Guiyang–Guangzhou high-speed railway, also known as the Guiguang HSR, is a high-speed railway line in southern China between Guiyang in Guizhou Province and Guangzhou in Guangdong Province. The railway is dedicated to high speed passenger rail service. The line is 856 km (532 mi) in length and can carry trains at speeds of up to 250 km/h (155 mph). The line was built from 2008 to 2014 and opened on December 26, 2014.

The high-speed rail (HSR) network in the People's Republic of China (PRC) is the world's longest and most extensively used – with a total length of 45,000 kilometres (28,000 mi) by the end of 2023. The HSR network encompasses newly built rail lines with a design speed of 200–380 km/h (120–240 mph). China's HSR accounts for two-thirds of the world's total high-speed railway networks. Almost all HSR trains, track and service are owned and operated by the China Railway Corporation under the brand China Railway High-speed (CRH).