Guy of Boulogne was a statesman and cardinal who served the Avignon Papacy for 33 years. He participated in the papal conclaves of 1352, 1362 and 1370, and was the Subdean of the Sacred College of Cardinals. His diplomatic postings were extensive, including Hungary, Italy, and Spain. He headed an effort to end the Hundred Years' War. The historian Kenneth Setton called him "one of the commanding figures of his day, and the letters of Petrarch abound with references to him".

The papal conclave held from 16 to 18 December 1352 was convened after the death of Pope Clement VI and elected as his successor Cardinal Etienne Aubert. The fifth pope of the period of the Avignon Papacy, he took the name Innocent VI. This conclave is remarkable because during its celebration cardinals for the first time in history subscribed the electoral capitulation, which limited the power of elect.