Guyanese Americans are American people with Guyanese ancestry or immigrants who were born in Guyana. Guyana is home to people of many different national, ethnic and religious origins. As of 2019, there are 231,649 Guyanese Americans currently living in the United States. The majority of Guyanese live in New York City – some 140,000 – making them the fifth-largest foreign-born population in the city.

Afro-Guyanese are generally descended from the enslaved people brought to Guyana from the coast of West Africa to work on sugar plantations during the era of the Atlantic slave trade. Coming from a wide array of backgrounds and enduring conditions that severely constrained their ability to preserve their respective cultural traditions contributed to the adoption of Christianity and the values of British colonists.