Guymon is a city and county seat of Texas County, in the panhandle of Oklahoma, United States. As of the 2020 census, the city population was 12,965, an increase of 13.3% from 11,442 in 2010, and represents more than half of the population of the county, along with being the largest city in the Oklahoma Panhandle. Cattle feedlots, corporate pork farms, and natural gas production dominate its economy, with wind energy production and transmission recently diversifying landowners' farms. Guymon was the only town or city in Oklahoma in 2010 and 2020 in which the majority of the population was Hispanic.

Texas County is a county located in the panhandle of the U.S. state of Oklahoma. Its county seat is Guymon. As of the 2020 census, the population was 21,384. It is the second largest county in Oklahoma, based on land area, and is named for Texas, the state that adjoins the county to its south. Texas County comprises the Guymon, OK Micropolitan Statistical Area. The county economy is largely based on farming and cattle production. It is one of the top-producing counties in the U.S. for wheat, cattle, and hogs. It also lies within the noted Hugoton-Panhandle natural gas field.