HER2
Videos
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene origin
1n8z: Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab
1s78: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Monoclonal antibody
Videos
A monoclonal antibody is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.
Looking at slides of cultures of cells that make monoclonal antibodies
Monoclonal antibodies can be grown in unlimited quantities in flasks.
Hand-filling wells with a liquid for a research test. This test involves preparation of cultures in which hybrids are grown in large quantities to produce desired antibody. This is effected by fusing a myeloma cell and a mouse lymphocyte to form a hybrid cell (hybridoma).
Bathing prepared slides in a solution