HMCS Regina is a Halifax-class frigate that has served in the Canadian Forces and Royal Canadian Navy since 1993. Regina is the fifth vessel in her class which is the name for the Canadian Patrol Frigate Project. She is the second vessel to carry the designation HMCS Regina. She is assigned to Maritime Forces Pacific (MARPAC) and is homeported at CFB Esquimalt.

The Halifax-class frigate, also referred to as the City class, is a class of multi-role patrol frigates that have served the Royal Canadian Navy since 1992. The class is the outcome of the Canadian Patrol Frigate Project, which dates to the mid-1970s. HMCS Halifax was the first of an eventual twelve Canadian-designed and Canadian-built vessels which combine traditional anti-submarine capabilities with systems to deal with surface and air threats as well. Ships of the class are named after capital cities of Canadian provinces, the capital of Canada, Ottawa, and the major cities of Calgary, Montreal, and Vancouver.