An H II region or HII region is a region of interstellar atomic hydrogen that is ionized. It is typically in a molecular cloud of partially ionized gas in which star formation has recently taken place, with a size ranging from one to hundreds of light years, and density from a few to about a million particles per cubic centimetre. The Orion Nebula, now known to be an H II region, was observed in 1610 by Nicolas-Claude Fabri de Peiresc by telescope, the first such object discovered.

A molecular cloud, sometimes called a stellar nursery (if star formation is occurring within), is a type of interstellar cloud, the density and size of which permit absorption nebulae, the formation of molecules (most commonly molecular hydrogen, H2), and the formation of H II regions. This is in contrast to other areas of the interstellar medium that contain predominantly ionized gas.