Hady Amr is an American government official serving as special representative for Palestinian affairs since 22 November 2022. He was previously Deputy Assistant Secretary for Israeli and Palestinian Affairs in the Bureau of Near Eastern Affairs within the U.S. Department of State. The new position is a significant upgrade in relations with Palestine. He was appointed to the role under President Joe Biden on January 20, 2021. He was born in Lebanon, and has close ties to the region, being praised by both Israeli and Palestinian leaders alike.

A major outbreak of violence in the ongoing Israeli–Palestinian conflict commenced on 10 May 2021, though disturbances took place earlier, and continued until a ceasefire came into effect on 21 May. It was marked by protests and police riot control, rocket attacks on Israel by Hamas and Palestinian Islamic Jihad (PIJ), and Israeli airstrikes in the Gaza Strip. The crisis was triggered on 6 May, when Palestinians in East Jerusalem began protesting over an anticipated decision of the Supreme Court of Israel on the eviction of six Palestinian families in the East Jerusalem neighborhood of Sheikh Jarrah. Under international law, the area, effectively annexed by Israel in 1980, is a part of the Israeli-occupied West Bank; On 7 May, according to Israel's Channel 12, Palestinians threw stones at Israeli police forces, who then stormed the Al-Aqsa Mosque compound using tear gas, rubber bullets, and stun grenades. The crisis prompted protests around the world as well as official reactions from world leaders.