The Hagerstown–Martinsburg metropolitan area, officially designated by the United States Office of Management and Budget (OMB) as Hagerstown–Martinsburg, Maryland–West Virginia Metropolitan Statistical Area (MSA), constitutes the primary cities of Hagerstown, Maryland; Martinsburg, West Virginia; and surrounding areas in three counties: Washington County, Maryland; Berkeley County, West Virginia; and Morgan County, West Virginia. The metro area lies mainly within the rich, fertile Cumberland and Shenandoah valleys, and is approximately a 60–90 minute drive from Washington, D.C.; Baltimore, Maryland; and Harrisburg, Pennsylvania; Hagerstown is approximately 75 miles (121 km) driving distance from all three cities. The population of the metropolitan area as of 2008 is 263,753.

Martinsburg is a city in and the county seat of Berkeley County, West Virginia, United States. The population was 18,773 at the 2020 census, making Martinsburg the largest city in the Eastern Panhandle of West Virginia and the sixth-most populous city in the state. It is a principal city of the Hagerstown–Martinsburg metropolitan area extending into Maryland, which had 293,844 residents in 2020.