Hamnet Shakespeare was the only son of William Shakespeare and Anne Hathaway, and the fraternal twin of Judith Shakespeare. He died at the age of 11. Some Shakespearean scholars speculate on the relationship between Hamnet and his father's later play Hamlet, as well as on possible connections between Hamnet's death and the writing of King John, Romeo and Juliet, Julius Caesar, and Twelfth Night.

Judith Quiney, née Shakespeare, was the younger daughter of William Shakespeare and Anne Hathaway and the fraternal twin of their only son Hamnet Shakespeare. She married Thomas Quiney, a vintner of Stratford-upon-Avon. The circumstances of the marriage, including Quiney's misconduct, may have prompted the rewriting of Shakespeare's will. Thomas was struck out, while Judith's inheritance was attached with provisions to safeguard it from her husband. The bulk of Shakespeare's estate was left, in an elaborate fee tail, to his elder daughter Susanna and her male heirs.