Hancock County is a county in the U.S. state of West Virginia. As of the 2020 census, the population was 29,095. Its county seat is New Cumberland and its largest city is Weirton. The county was created from Brooke County in 1848 and named for John Hancock, first signer of the Declaration of Independence. Located at the tip of the state's Northern Panhandle, Hancock County is the northernmost point in both West Virginia and, by some definitions, the Southern United States. Hancock County is part of the Weirton-Steubenville, WV-OH Metropolitan Statistical Area, which is also included in the Pittsburgh-New Castle-Weirton, PA-WV-OH Combined Statistical Area.

Weirton is a city in Hancock and Brooke counties in the U.S. state of West Virginia. Located along the Ohio River in the state's Northern Panhandle, the city's population was 19,163 as of the 2020 census, making it the seventh most populous city in the state.