Handan Sultan was a consort of Ottoman Sultan Mehmed III, and mother and Valide Sultan to their son Sultan Ahmed I.

Mehmed III was the sultan of the Ottoman Empire from 1595 until his death in 1603. Mehmed was known for ordering the execution of his brothers and leading the army in the Long Turkish War, during which the Ottoman army was victorious at the decisive Battle of Keresztes. This victory was however undermined by some military losses such as in Gyor and Nikopol. He also ordered the successful quelling of the Jelali rebellions. The sultan also communicated with the court of Elizabeth I on the grounds of stronger commercial relations and in the hopes of England to ally with the Ottomans against the Spanish.