Happy Hooligan is an American comic strip, the first major strip by the already celebrated cartoonist Frederick Burr Opper. It debuted with a Sunday strip on March 11, 1900 in the William Randolph Hearst newspapers, and was one of the first popular comics with King Features Syndicate. The strip ran for three decades, ending on August 14, 1932.

Frederick Burr Opper was one of the pioneers of American newspaper comic strips, best known for his comic strip Happy Hooligan. His comic characters were featured in magazine gag cartoons, covers, political cartoons and comic strips for six decades.