Harlem is a neighborhood in Upper Manhattan, New York City. It is bounded roughly by the Hudson River on the west; the Harlem River and 155th Street on the north; Fifth Avenue on the east; and Central Park North on the south. The greater Harlem area encompasses several other neighborhoods and extends west and north to 155th Street, east to the East River, and south to Martin Luther King Jr. Boulevard, Central Park, and East 96th Street.

155th Street is a crosstown street separating the Harlem and Washington Heights neighborhoods, in the New York City borough of Manhattan. It is the northernmost of the 155 crosstown streets mapped out in the Commissioner's Plan of 1811 that established the numbered street grid in Manhattan.