Harpersville is a town in Shelby County, Alabama, United States. According to the 1950 U.S. Census, it formally incorporated in 1943. At the 2020 census the population was 1,614, compared to 1,637 in 2010 and 1,620 in 2000. It is located southeast of the Birmingham metro area.

Shelby County is located in the central portion of the U.S. state of Alabama. As of the 2020 census the population was 223,024, making it the sixth-most populous county in Alabama. The county seat is Columbiana. Its largest city is Alabaster. The county is named in honor of Isaac Shelby, Governor of Kentucky from 1792 to 1796 and again from 1812 to 1816. Shelby County is included in the Birmingham–Hoover, AL Metropolitan Statistical Area.