Harris & Frank was a clothing retailer and major chain in the history of retail in Southern California, which at its peak had around 40 stores across Southern California and in neighboring states and regions. Its history dates back to a clothing store founded by Leopold Harris in Los Angeles in 1856 near the city's central plaza, only eight years after the city had passed from Mexican to American control. Herman W. Frank joined Harris in partnership 32 years later in 1888.

Retail in Southern California dates back to its first dry goods store that Jonathan Temple opened in 1827 on Calle Principal, when Los Angeles was still a Mexican village. After the American conquest, as the pueblo grew into a small town surpassing 4,000 population in 1860, dry goods stores continued to open, including the forerunners of what would be local chains. Larger retailers moved progressively further south to the 1880s-1890s Central Business District, which was later razed to become the Civic Center. Starting in the mid-1890s, major stores moved ever southward, first onto Broadway around 3rd, then starting in 1905 to Broadway between 4th and 9th, then starting in 1915 westward onto West Seventh Street up to Figueroa. For half a century Broadway and Seventh streets together formed one of America's largest and busiest downtown shopping districts.