The Harrison County School District is a public school district based in Gulfport, Mississippi, United States.

Gulfport is the second-most populous city in the U.S. state of Mississippi after the state capital, Jackson. Along with Biloxi, Gulfport is the co-county seat of Harrison County and part of the Gulfport–Biloxi metropolitan area. As of the 2020 census, Gulfport has a population of 72,926; the metro area has a population of 416,259. Gulfport lies along the gulf coast of the United States in southern Mississippi, taking its name from its port on the Gulf Coast on the Mississippi Sound. It is home to the U.S. Navy Atlantic Fleet Seabees.