Harry S. Truman High School is a public high school at 750 Baychester Avenue, in the Co-op City section of the Bronx, New York City, United States. The school is designated as an Empowerment School by the New York City Department of Education, which allows it more autonomy in choosing a curriculum. Truman shares a uniquely designed and interconnected campus with two middle schools, MS 180 and 181, and two elementary schools, PS 178 and 153. The campus was designed to be a one-stop and close-to-home solution for students and families in the Co-op City neighborhood, although many of the students commute to school from other parts of the city. The main Truman building is also home to the Bronx Health Sciences High School, which occupies a portion of the third floor, and PS 176X, a special education school for autistic students, which shares a small portion of the first and second floors.

Co-op City is a cooperative housing development located in the northeast section of the borough of the Bronx in New York City. It is bounded by Interstate 95 to the southwest, west, and north and the Hutchinson River Parkway to the east and southeast, and is partially in the Baychester and Eastchester neighborhoods. With 43,752 residents as of the 2010 United States Census, it is the largest housing cooperative in the world. It is in New York City Council District 12.