Hartsville is the largest city in Darlington County, South Carolina, United States. It was chartered on December 11, 1891. The population was 7,764 at the 2010 census. Hartsville was chosen as an All-America City in 1996 and again in 2016. Hartsville has also been a National Arbor Day Foundation Tree City since 1986.

Darlington County is a county in the U.S. state of South Carolina. As of the 2020 census, its population was 62,905. Its county seat is Darlington. Hartsville is the largest community in the county. Darlington County is home to the Darlington Raceway, which hosts the annual NASCAR Southern 500. Darlington County is also home to Coker College in Hartsville. Darlington County was named by an act in March 1785.