The Hartsville Nuclear Plant is a canceled nuclear power plant project located near Hartsville, Tennessee. To be built and operated by the Tennessee Valley Authority, it was to have four General Electric boiling water reactors.

Hartsville is a town in Trousdale County, Tennessee, United States. It is the county seat of Trousdale County, with which it shares a consolidated city-county government. The population of Hartsville was 11,615 as of 2020.