Harvard Square is a triangular plaza at the intersection of Massachusetts Avenue, Brattle Street and John F. Kennedy Street near the center of Cambridge, Massachusetts, United States. The term "Harvard Square" is also used to delineate the business district and Harvard University surrounding that intersection, which is the historic center of Cambridge. Adjacent to Harvard Yard, the historic heart of Harvard University, the Square functions as a commercial center for Harvard students, as well as residents of western Cambridge, the western and northern neighborhoods and the inner suburbs of Boston. The Square is served by Harvard station, a major MBTA Red Line subway and a bus transportation hub.

Massachusetts Avenue is a major thoroughfare in Boston, Massachusetts, and several cities and towns northwest of Boston. According to Boston magazine, "Its 16 miles of blacktop run from gritty industrial zones to verdant suburbia, homeless encampments, passing gentrified brownstones, college campuses and bustling commercial strips."