The Hatfield Marine Science Center (HMSC) is a marine science research and education center next to Yaquina Bay of the Pacific Ocean in the U.S. state of Oregon. It is operated by Oregon State University in cooperation with five state and federal agencies co-located on site. Named after Mark Hatfield, a former U.S. Senator from Oregon, the HMSC occupies a 49-acre (20 ha) site in Newport.

Yaquina Bay is a coastal estuarine community found in Newport, Oregon. Yaquina Bay is a semi-enclosed body of water, approximately 8 km2 (3.2 mi2) in area, with free connection to the Pacific Ocean, but also diluted with freshwater from the Yaquina River land drainage. The Bay is traversed by the Yaquina Bay Bridge.