Hazelwood Central High School is located at 15875 New Halls Ferry Road in unincorporated St. Louis County, Missouri, adjacent to the current northeast boundary of Florissant. The school is one of three high schools in Hazelwood School District (HSD), the others being Hazelwood East High School and Hazelwood West High School.

Florissant is a city in St. Louis County, Missouri, within Greater St. Louis. It is a middle-class, second-ring northern suburb of St. Louis. Based on the 2020 United States census, the city had a total population of 52,533.