Headington School is an independent girls' school in Headington, Oxford, England, founded by a group of evangelical Christians in 1915.

Headington is an eastern suburb of Oxford, in the county of Oxfordshire, England. It is at the top of Headington Hill overlooking the city in the Thames valley below, and bordering Marston to the north-west, Cowley to the south, and Barton and Risinghurst to the east. The life of the large residential area is centred upon London Road, the main road between London and Oxford.