William Hickling Prescott House, also known as the Headquarters House, is an historic house museum located at 55 Beacon Street on Beacon Hill in Boston, Massachusetts. It is the left-hand portion of a double townhouse at 54–55 Beacon Street, seen in the photograph. The townhouse, built in 1808 to a design by Asher Benjamin, was designated a National Historic Landmark in 1964 for its association with William Hickling Prescott (1796–1859), one of the nation's first historians. The house is now a museum operated by the Massachusetts chapter of the National Society of the Colonial Dames of America, which purchased it for its headquarters in 1944.

Asher Benjamin was an American architect and author whose work transitioned between Federal architecture and the later Greek Revival architecture. His seven handbooks on design deeply influenced the look of cities and towns throughout New England until the Civil War. Builders also copied his plans in the Midwest and in the South.