William Hickling Prescott House, also known as the Headquarters House, is an historic house museum located at 55 Beacon Street on Beacon Hill in Boston, Massachusetts. It is the left-hand portion of a double townhouse at 54–55 Beacon Street, seen in the photograph. The townhouse, built in 1808 to a design by Asher Benjamin, was designated a National Historic Landmark in 1964 for its association with William Hickling Prescott (1796–1859), one of the nation's first historians. The house is now a museum operated by the Massachusetts chapter of the National Society of the Colonial Dames of America, which purchased it for its headquarters in 1944.

Beacon Street is a major thoroughfare in Boston, Massachusetts, and its western suburbs of Brookline and Newton. It passes through many of Boston's central and western neighborhoods, including Beacon Hill, Back Bay, Fenway–Kenmore, the Boston University campus, Brighton, and Chestnut Hill.