Heidelberg Hauptbahnhof is the main railway station for the city of Heidelberg. In 2005 it was used by around 42,000 passengers per day and is one of the largest passenger stations in the German state of Baden-Württemberg. The station is classified by Deutsche Bahn as a category 2 station.

The Mannheim–Karlsruhe–Basel railway is a double-track electrified mainline railway in the German state of Baden-Württemberg. It runs from Mannheim via Heidelberg, Bruchsal, Karlsruhe, Rastatt, Baden-Baden, Offenburg and Freiburg to Basel, Switzerland. It is also known as the Rhine Valley Railway or the Upper Rhine Railway (Oberrheinbahn).