The Senator John Heinz History Center, an affiliate of the Smithsonian Institution, is the largest history museum in the Commonwealth of Pennsylvania, United States. Named after U.S. Senator H. John Heinz III (1938–1991) from Pennsylvania, it is located in the Strip District of Pittsburgh.

Henry John Heinz III was an American businessman and politician who served as a United States senator from Pennsylvania from 1977 until his death in 1991. An heir to the Heinz family fortune, Heinz entered politics in 1971 when he won a special election to replace Robert Corbett to represent Pennsylvania's 18th congressional district. In 1976, Heinz ran to replace retiring Senate Minority Leader Hugh Scott. Heinz narrowly won in the primary over future Senator Arlen Specter, and defeated William Green III. Heinz won re-election in 1982 and 1988 by large margins. On April 4, 1991, Heinz was killed when his plane, facing mechanical problems, collided with a helicopter inspecting the plane, killing all involved in the crash.