Helena Cassadine is a fictional character who is the main antagonist of the American soap opera General Hospital, famously originated by film actress Elizabeth Taylor in November 1981. After a brief stint by Dimitra Arliss in 1996, Constance Towers took over the role in 1997 and has returned — for periods of varying length — nearly every year since.

Emily Quartermaine is a fictional character from the ABC soap opera General Hospital. The role was originated on January 20, 1995 by Amber Tamblyn, who portrayed the role until July 11, 2001. Natalia Livingston subsequently played Emily from April 1, 2003 until May 7, 2008, despite the character's death in November 2007. Livingston also appeared for two episodes in 2009, last appearing on June 23. Livingston made a surprise return for the show's 50th anniversary, appearing on April 2, 2013. She returned once again on March 18, 2014 & April 1, 2014. In 2005, Livingston won the Daytime Emmy Award for Outstanding Supporting Actress in a Drama Series for her portrayal of Emily.