Stephen Hempstead High School is a four-year public high school located in Dubuque, Iowa. It is one of two high schools in the Dubuque Community School District and enrolls around 1,800 students in grades 9–12. The school is named in honor of Stephen Hempstead, the second governor of Iowa, and it competes in class 4A of the Iowa High School Athletic Association as part of the Mississippi Valley Conference. The school's mascot is the Mustang.

Dubuque is a city in and the county seat of Dubuque County, Iowa, United States, located along the Mississippi River. At the time of the 2020 census, the population of Dubuque was 59,667. The city lies at the junction of Iowa, Illinois, and Wisconsin, a region locally known as the Tri-State Area. It serves as the main commercial, industrial, educational, and cultural center for the area. Geographically, it is part of the Driftless Area, a portion of North America that escaped all three phases of the Wisconsin Glaciation.