Henderson County is a county in the U.S. state of Kentucky. The county is located in western Kentucky on the Ohio River across from Evansville, Indiana. As of the 2020 census, the population was 44,793. Its county seat is Henderson.

Evansville is a city in and the county seat of Vanderburgh County, Indiana, United States. With a population of 118,414 at the 2020 census, it is Indiana's third-most populous city after Indianapolis and Fort Wayne, the most populous city in Southern Indiana, and the 249th-most populous city in the United States. It is the central city of the Evansville metropolitan area, a hub of commercial, medical, and cultural activity of southwestern Indiana and the Illinois–Indiana–Kentucky tri-state area, which is home to over 911,000 people. The 38th parallel north crosses the north side of the city and is marked on Interstate 69 immediately north of its junction with Indiana 62 within the city's east side.