Henderson County is a county located in the U.S. state of Tennessee. As of the 2020 census, the population was 27,842. Its county seat is Lexington. The county was founded in 1821 and named for James Henderson, a soldier in the War of 1812.

Lexington is a city in Henderson County, Tennessee, United States. Lexington is midway between Memphis and Nashville, lying 10 miles (16 km) south of Interstate 40, which connects the two cities. The population was 7,956 at the 2020 census. It is the county seat of Henderson County.