Henderson County is a county located in the U.S. state of Tennessee. As of the 2020 census, the population was 27,842. Its county seat is Lexington. The county was founded in 1821 and named for James Henderson, a soldier in the War of 1812.

West Tennessee is one of the three Grand Divisions of Tennessee that roughly comprises the western quarter of the state. The region includes 21 counties between the Tennessee and Mississippi rivers, delineated by state law. Its geography consists primarily of flat lands with rich soil and vast floodplain areas of the Mississippi River. Of the three regions, West Tennessee is the most sharply defined geographically, and is the lowest-lying. It is both the least populous and smallest, in land area, of the three Grand Divisions. Its largest city is Memphis, the state's second most populous city.