Henderson State University (HSU) is a public university in Arkadelphia, Arkansas, Founded in 1890 as Arkadelphia Methodist College. Henderson has an undergraduate enrollment of around 2,500 students. The campus is located on 156 acres (0.63 km2).

Arkadelphia is a city in Clark County, Arkansas, United States. As of the 2020 census, the population was 10,380. The city is the county seat of Clark County. It is situated at the foothills of the Ouachita Mountains. Two universities, Henderson State University and Ouachita Baptist University, are located here. Arkadelphia was incorporated in 1857.