Henry: Portrait of a Serial Killer is a 1986 American independent psychological horror crime film directed and co-written by John McNaughton about the random crime spree of a serial killer who seemingly operates with impunity. It stars Michael Rooker in his film debut as the nomadic killer Henry, Tom Towles as Otis, a prison buddy with whom Henry is living, and Tracy Arnold as Becky, Otis's sister. The characters of Henry and Otis are loosely based on convicted real life serial killers Henry Lee Lucas and Ottis Toole.

Michael Rooker is an American actor who mainly plays roles of antagonists. He first rose to prominence for portraying Henry in Henry: Portrait of a Serial Killer (1986), and is best known for starring as Merle Dixon in the AMC series The Walking Dead (2010–2013) and as Yondu Udonta in Guardians of the Galaxy (2014), followed by its sequels Guardians of the Galaxy Vol. 2 (2017) and Guardians of the Galaxy Vol. 3 (2023). He is a recurring collaborator of Guardians of the Galaxy director and co-CEO of DC studios James Gunn, appearing in his films Slither (2006), Super (2010) and The Suicide Squad (2021).