Henry Frederick, Prince of Wales,, was the eldest son and heir apparent of James VI and I, King of England and Scotland; and his wife Anne of Denmark. His name derives from his grandfathers: Henry Stuart, Lord Darnley; and Frederick II of Denmark. Prince Henry was widely seen as a bright and promising heir to his father's thrones. However, at the age of 18, he predeceased his father, dying of typhoid fever. His younger brother Charles succeeded him as heir apparent to the English, Irish, and Scottish thrones.

Anne of Denmark was the wife of King James VI and I. She was Queen of Scotland from their marriage on 20 August 1589 and Queen of England and Ireland from the union of the Scottish and English crowns on 24 March 1603 until her death in 1619.