Henry II, known as "the Good ", was Duke of Lorraine from 1608 until his death. Leaving no sons, both of his daughters became Duchesses of Lorraine by marriage. He was a brother-in-law of Henry IV of France.

Eleanor de' Medici was a Duchess of Mantua by marriage to Vincenzo I Gonzaga. She served as regent of Mantua 1595, 1597 and 1601, when Vincenzo served in the Austrian campaign in Hungary, and in 1602, when he left for Flanders for medical treatment. She was a daughter of Francesco I de' Medici and Joanna of Austria and the sister of Marie de' Medici, Queen of France.