Henry Morgan's Panama expedition also known as the Sack of Panama, was an expedition that took place between 16 December 1670 and 5 March 1671 during the later stage of the Anglo-Spanish War. English privateers and French pirates commanded by notable Buccaneer Henry Morgan launched an attack with an army of 1,400 men with the purpose of capturing the rich Spanish city of Panama off the Pacific coast.

The Anglo-Spanish War was a conflict between the English Protectorate under Oliver Cromwell, and Spain, between 1654 and 1660. It was caused by commercial rivalry. Each side attacked the other's commercial and colonial interests in various ways such as privateering and naval expeditions. In 1655, an English amphibious expedition invaded Spanish territory in the Caribbean. In 1657, England formed an alliance with France, merging the Anglo–Spanish war with the larger Franco-Spanish War resulting in major land actions that took place in the Spanish Netherlands.