Henry VIII was King of England from 22 April 1509 until his death in 1547. Henry is known for his six marriages and his efforts to have his first marriage annulled. His disagreement with Pope Clement VII about such an annulment led Henry to initiate the English Reformation, separating the Church of England from papal authority. He appointed himself Supreme Head of the Church of England and dissolved convents and monasteries, for which he was excommunicated by the pope.

Thomas Wolsey was an English statesman and Catholic cardinal. When Henry VIII became King of England in 1509, Wolsey became the king's almoner. Wolsey's affairs prospered and by 1514 he had become the controlling figure in virtually all matters of state. He also held important ecclesiastical appointments. These included the Archbishop of York—the second most important role in the English church—and that of papal legate. His appointment as a cardinal by Pope Leo X in 1515 gave him precedence over all other English clergy.