Hephestion was a British Thoroughbred racehorse and best known for winning the classic 2000 Guineas in 1810. The rest of his racing career was undistinguished, as he recorded only four other victories in minor contests from a total of eighteen competitive races. He does not appear to have found a place at stud as a breeding stallion.

The 2000 Guineas Stakes is a Group 1 flat race in Great Britain open to three-year-old thoroughbred colts and fillies. It is run on the Rowley Mile at Newmarket over a distance of 1 mile (1.6 km) and scheduled to take place each year at the start of May.