Heppenheim (Bergstraße) is the seat of Bergstraße district in Hesse, Germany, lying on the Bergstraße on the edge of the Odenwald. It is best known for being the birthplace of Sebastian Vettel, a four-time Formula One World Champion and the place of founding of the Free Democratic Party (Germany).

The Bergstraße is an 80-kilometre-long (50 mi) ancient trade route in the south-west of Germany. The route and the area around it is a mountainous "theme route" running north–south along the western edge of the Odenwald forest in southern Hesse and northern Baden-Württemberg. The route passes through the Bergstraße administrative district, and independent viticultural regions of Hessische Bergstraße and Badische Bergstraße. Between the cities of Heidelberg and Weinheim the Upper Rhine Railway Company (OEG) tram route runs alongside.