Hernando is the county seat of DeSoto County, on the northwestern border of Mississippi, United States. The population was 17,138 according to the 2020 census records. DeSoto County is the second-most-populous county in the Memphis metropolitan area, which includes counties in Tennessee, Arkansas and Mississippi.

DeSoto County is a county located on the northwestern border of the U.S. state of Mississippi. As of the 2020 census, the population was 185,314, making it the third-most populous county in Mississippi. Its county seat is Hernando.