A hexokinase is an enzyme that irreversibly phosphorylates hexoses, forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the
Hexokinase 1, homodimer, Human
crystal structure of human glucokinase
rat brain hexokinase type i complex with glucose and inhibitor glucose-6-phosphate
Glycolysis is the metabolic pathway that converts glucose into pyruvate and, in most organisms, occurs in the liquid part of cells. The free energy released in this process is used to form the high-en
Hexokinase
…an accessible -CH2OH moiety. Phosphorylation of a hexose such as glucose often limits it to a number of intracellular metabolic processes, such as glycolysis or glycogen synthesis. This is because phosphorylated hexoses are charged, and thus more difficult to transport out of a cell. In patients with essential…
Summary of aerobic respiration
Eduard Buchner discovered cell-free fermentation.
Otto Meyerhof, one of the main scientists involved in completing the puzzle of glycolysis