Hierapolis was originally a Phrygian cult centre of the Anatolian mother goddess of Cybele and later a Greek city. Its location was centred upon the remarkable and copious hot springs in classical Phrygia in southwestern Anatolia. Its extensive remains are adjacent to modern Pamukkale in Turkey.

In classical antiquity, Phrygia was a kingdom in the west-central part of Anatolia, in what is now Asian Turkey, centered on the Sangarios River. After its conquest, it became a region of the great empires of the time.